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Have a Deeper Look at The History of Dapoxetine

Priligy (dapoxetine hydrochloride) is the first oral medication to be approved for the treatment of premature ejaculation. It was by chance that they discovered its ability to treat premature ejaculation, actually developed to treat depression. In this electronic resource (e-source), we’ll use the Viagra™ story to show how a medicine is designed, developed and produced As an active ingredient in Priligy, dapoxetine hydrochloride belongs to the class of medicines called selective serotonin reuptake inhibitors (SSRIs) with a short half-life of 1 or 2 hours, it is considered safe and sound for the treatment of premature ejaculation. At the initial development of dapoxetine, it has been credited by some sources to Eli Lilly chemist David Wong, who was also one of the developers of fluoxetine (Prozac). Like Prozac and other antidepressants such as Zoloft, Escitalopram and Paxil, dapoxetine is SSRI. In fact, considering the drug’s early development over a decade ago, Eli Lilly began phase I clinical trials for dapoxetine as an antidepressant medication. But dapoxetine was put on hold for a while and didn’t pan out as an antidepressant. But the same thing that leads to its failure as a psychopharmaceutical turned out to be the cause for its success as a premature ejaculation treatment.

Dapoxetine as a SRRI

Similar to other SSRIs, dapoxetine has the effect of delaying ejaculation and orgasm, and for a while doctors have been prescribing other SSRIs to treat premature ejaculation. But, as these antidepressants for treating this condition are not approved by the FDA, this is considered for “off label” use. As unlike other SSRIs, dapoxetine is easily and rapidly absorbed and eliminated by the body i.e. within few hours, rather than days. It was Karl Thor an Eli Lilly researcher who realized the drug’s potential as a treatment particularly for premature ejaculation. Due to its short residence in the body, it is considered unfeasible as an antidepressant. But on the other hand makes it more suitable for treating premature ejaculation. Eli Lilly resumed several trials with the remedy, but this time as a treatment for premature ejaculation.

Who Owns Priligy dapoxetine?

The patents and rights for the remedy have changed sometimes, and a number of pharmaceutical companies have owned the rights to dapoxetine. The drug was originated by Eli Lilly, but in 1998, to develop the drug as a premature ejaculation treatment, PPD GenuPro acquired the rights from Eli Lilly. But in 2001, PPD sold exclusive worldwide marketing and development rights for dapoxetine to an affiliate of Johnson & Johnson, ALZA Corporation. In 2003, PPD bought the patents for dapoxetine from Eli Lilly. PPD will still get milestone payments and drug royalties from ALZA, even if ALZA is the current license holder. However, if PPD exceed a certain amount Eli Lilly may possibly receive royalties from it. Now-a-days dapoxetine will be marketed in Canada by Janssen-Ortho Inc., in US by Ortho McNeil, and is currently being marketed in Europe by Janssen-Cilag; all are units of Johnson & Johnson.

Why Priligy (dapoxetine) is a safe drug?

Eli Lilly carried out the initial clinical trials of dapoxetine (phase I) for FDA approval. In collaboration with PPD GenuPro the phase II trials is executed. PPD presented the findings of two major trials in 2005 after continuing with phase III trials. Doses of 60mg or 100mg of dapoxetine were given to the men having age between 18 and 65 resulting in improved length of time to ejaculate. In 2008, dapoxetine had been tested with over 6,000 subjects in five major phase III trials. It was found that dapoxetine was not only increasing the intravaginal ejaculatory latency time but also improves overall sexual satisfaction and the sense of control over ejaculation.
It has been submitted for approval in the European Union and is being reviewed. In 2009, it’s been approved in Sweden, Finland, Austria, Portugal, Germany, Italy and Spain. And approvals are also anticipated in other European countries as well. In addition to this, in Canada, Australia, Mexico, Turkey and six other countries the submissions for approval have been done.

Treat Premature Ejaculation With Dapoxetine

Premature ejaculation is a problem that affects a significant number of men and this has serious consequences on the sexual life of these individuals. Therefore, it is essential for people who suffer from premature ejaculation to take action and to consider dapoxetine, which is a drug that was created specifically for the treatment of premature ejaculation. If you would like to buy dapoxetine and to find more about this medicine, online you will come across all the information you need! Dapoxetine is a unique inhibitor and it should be taken 1-3 hours before sexual intercourse is anticipated and not every day.

Premature ejaculation is a stressful dysfunction that occurs either from the first sexual encounter or it develops later on in life. Unfortunately numerous men are affected by this sooner or later and it is said that premature ejaculation is created by physiological and psychological factors which affect the ejaculation mechanism. Nonetheless, men who would like to increase the duration of sex and improve their sex life should definitely buy dapoxetine. First of all, dapoxetine is a drug with no severe side effects and the most common side effects you might experience if you take dapoxetine are headache, nausea, diarrhea, insomnia and fatigue.

Second of all, if you want to buy dapoxetine you should know that it has a bitter taste and that it should be taken with a glass of water, it should be not be used by children under 18 and it should not be administered together with drugs with serotonergic activity. Also, dapoxetine should not be taken more than once in 24 hours, especially if you want to avoid any side effects and to make sure that the drug works. Men who would like to buy dapoxetine can choose from generic and brand dapoxetine. The branded drug is a bit more expensive and it is available in a specific color and packaging while the generic is more accessible from a financial point of view and widely available.

The good news for men who desire to buy dapoxetine is that online they will find numerous providers that offer dapoxetine at very competitive prices. We should also mention the fact that this drug really works and that it will change your sexual life provided you are willing to give it a try. After all, premature ejaculation is a frustrating problem and if you want to do something about it, you should definitely consider dapoxetine. Why should you have a disastrous sex life when you can take this drug and enjoy a healthy, fulfilling sex life?
We know how frustrating it can be not to have a sex life because of premature ejaculation and we strive to put at your disposal at competitive prices dapoxetine a drug that works wonders. Thus, if you want to buy dapoxetine you have come to the best place!

Priligy Is A New Medication For Men

In Europe, a new drug has recently received regulatory approval in many countries and is now undergoing phase III testing in the United States. This novel new medicine is called dapoxetine and is being sold and marketed as Priligy by the pharmaceutical company , Janssen-Cilag. Men in countries across Europe are now acquiring Priligy online. These men have discovered a successful treatment for a condition that has been the source of stress and anxiety for men since the beginning of time. In fact, it is estimated that 20-30% of sexually active men regularly suffer from the problem that Priligy treats.

So you may be asking yourself at this point, what is Priligy and what condition does it cure? Also, once you find out the answer to that question you may then ask , where can I buy Priligy? Well, the answer to question #1 above is simple, yet delicate. You see, Priligy has been developed for the treatment of PE , which is an abbreviation for premature ejaculation. For the sake of modesty , we will refer to it hereafter as PE. Needless to say , PE is a very sensitive issue and/or problem for many males of all ethnic and social backgrounds. Priligy is being heralded as the long desired cure for PE.

Priligy is a short-acting selective serotonin reuptake inhibitor. Serotonin is a chemical naturally occuring in your body that may extend time to ejaculation, by slowing the pathways in the body that are associated with PE. The maker of Priligy, Janssen-Cilag explains how Priligy works… “PRILIGY can increase sense of control over ejaculation and time to ejaculation. During treatment with PRILIGY, increased time to ejaculation leads to an increased sense of control over ejaculation. Feeling more in control can reduce frustration or worry about how fast ejaculation occurs and increase satisfaction with sexual intercourse.”

So the next question that may come to mind is, how do I know if I have PE and if Priligy is for me? Well, of course, as with any medical condition , advice from a medical professional is indispensable for understanding your own body and knowing what treatments can be beneficial. However, some general information for determining if you may suffer from PE can be summed up by the following facts.

First of all, PE can be caused by biological factors or psychological or a combination of the two. Medical professionals generally classify PE as either lifelong (primary) or acquired (secondary). Obviously, men who are classified in the former are excellent candidates for Priligy as their condition has always been present and is likely biological in nature. According to the International Society for Sexual Medicine, lifelong PE is characterized by :

Ejaculation that always or nearly always occurs within 1-2 minutes or less of vaginal penetration
The inability to delay ejaculation on all or nearly all vaginal penetrations
Negative personal consequences, such as distress, frustration or the avoidance of sexual intimacy

Men who are classified in the latter (secondary) may also be good candidates for Priligy though their condition may be more psychological in nature, they can still benefit from Priligy if they take it together with psychological treatment, as it can provide beneficial assistance with control.

So from the aformentioned information you can get a solid understanding about Priligy and about PE, the health issue that it treats. So if you and your doctor determine that Priligy is right for you, you may wish to buy Priligy online. Since Priligy and PE are very sensitive topics for most men, the thought of going to the Internet to buy Priligy online is very appealing to most. By making an order for Priligy online you can take advantage of an online consultation as well as save a lot of money by acquiring Priligy at wholesale prices that many online pharmacies can provide .